KEGG   Homo sapiens (human): 7298
Entry
7298              CDS       T01001                                 
Symbol
TYMS, DKCD, HST422, TMS, TS
Name
(RefSeq) thymidylate synthetase
  KO
K00560  thymidylate synthase [EC:2.1.1.45]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate
hsa01100  Metabolic pathways
hsa01232  Nucleotide metabolism
hsa01523  Antifolate resistance
Module
hsa_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Disease
H00507  Dyskeratosis congenita
Drug target
Arfolitixorin (DG03254): D11447 D12528
Capecitabine: D01223<JP/US>
Carmofur: D01784
Doxifluridine: D01309<JP>
Floxuridine: D04197<US>
Fluorouracil (DG00687): D00584<JP/US> D07974
Fosifloxuridine nafalbenamide: D12388
Metesind glucuronate: D04964
Pemetrexed (DG00682): D03828<US> D06503<JP/US> D07472<US> D10596<JP/US> D11352<US>
Plevitrexed: D10803
Raltitrexed: D01064
Tegafur: D01244
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    7298 (TYMS)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    7298 (TYMS)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    7298 (TYMS)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     7298 (TYMS)
SSDB
Motif
Pfam: Thymidylat_synt
Other DBs
NCBI-GeneID: 7298
NCBI-ProteinID: NP_001062
OMIM: 188350
HGNC: 12441
Ensembl: ENSG00000176890
UniProt: P04818 Q53Y97
Structure
Position
18:657653..673578
AA seq 313 aa
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
NT seq 942 nt   +upstreamnt  +downstreamnt
atgcctgtggccggctcggagctgccgcgccggcccttgccccccgccgcacaggagcgg
gacgccgagccgcgtccgccgcacggggagctgcagtacctggggcagatccaacacatc
ctccgctgcggcgtcaggaaggacgaccgcacgggcaccggcaccctgtcggtattcggc
atgcaggcgcgctacagcctgagagatgaattccctctgctgacaaccaaacgtgtgttc
tggaagggtgttttggaggagttgctgtggtttatcaagggatccacaaatgctaaagag
ctgtcttccaagggagtgaaaatctgggatgccaatggatcccgagactttttggacagc
ctgggattctccaccagagaagaaggggacttgggcccagtttatggcttccagtggagg
cattttggggcagaatacagagatatggaatcagattattcaggacagggagttgaccaa
ctgcaaagagtgattgacaccatcaaaaccaaccctgacgacagaagaatcatcatgtgc
gcttggaatccaagagatcttcctctgatggcgctgcctccatgccatgccctctgccag
ttctatgtggtgaacagtgagctgtcctgccagctgtaccagagatcgggagacatgggc
ctcggtgtgcctttcaacatcgccagctacgccctgctcacgtacatgattgcgcacatc
acgggcctgaagccaggtgactttatacacactttgggagatgcacatatttacctgaat
cacatcgagccactgaaaattcagcttcagcgagaacccagacctttcccaaagctcagg
attcttcgaaaagttgagaaaattgatgacttcaaagctgaagactttcagattgaaggg
tacaatccgcatccaactattaaaatggaaatggctgtttag

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